Mature Dendritic Cells Express Functional Thrombin Receptors Triggering Chemotaxis and CCL18/Pulmonary and Activation-Regulated Chemokine Induction
نویسندگان
چکیده
منابع مشابه
Generation of Mature Monocyte-Derived Dendritic Cells in the Presence of Heparin and Monocyte Conditioned Medium: Phenotypic and Functional Comparison
Background: Dendritic cells (DC) induce tumor or pathogen-specific T cell responses in humans. Several laboratories have developed culture systems, including maturation factors for human DC from peripheral blood monocytes. We comprehensively compared standard maturation stimulus, an autologous monocyte-conditioned medium (MCM), with heparin for their ability to promote uniformly mature DC that ...
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T he migration of T cells is a highly regulated process, serving to distribute functional subsets of cells to the appropriate tissue or microenvironment. The role of adhesion molecules in this process is well appreciated (1, 2) however an additional class of molecules, the chemoattrac-tant cytokines (chemokines) and their receptors, are now receiving considerable attention, because of their fun...
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Cells of the dendritic lineage are thought to be among the first cells infected after mucosal exposure to HIV. In this study, we have identified the presence of multiple chemokine receptors on dendritic cells (DC) that may function as coreceptors for HIV entry. DC effectively used CCR5 for entry of macrophage (M)-tropic isolates. CCR3, the eotaxin receptor, initially identified on eosinophils, ...
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BACKGROUND Interleukin (IL)-33, a new member of the IL-1 cytokine family, is involved in T helper (Th)2-type responses in a wide range of diseases and is mediated by expression of the ST2 receptor in many immune cells. As the effects of IL-33 on dendritic cells (DCs) remain controversial, we investigated the ability of IL-33 to modulate the functions of these cells. METHODS DCs were derived f...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2008
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.181.2.1215